God, AIDS, Africa & HOPE

Reflections / Gedanken

Interview

Interview with a journalist from the WDR radio – and once again I am reminded how different the situation is in Europe and in Africa. Once again I count all our blessings but also have to list all our challenges: more people on treatment but definitely a growing risk of resistance due to the fact, that medication is not taken as prescribed or discontinued for a while. And yes more people know about the pandemic, but knowing does not mean that they act accordingly. Knowing about HIV does not prevent unprotected sex in many instances, having HIV/AIDS in the curricula of schools or NGO’s or other institutions and companies does not mean that the stigma is going away.
People are still killed or silenced or kicked out when they reveal their infection – people still think it can only be the others but not my partner who is infected. People still go for a test but disappear before the result is revealed. We still have the pre-test counselling which might be a nice way of giving unemployed people a little stipend or allowance, but does it really make sense to scare the willing people off or to have badly trained counsellors – some of them also infected – projecting their fears on the poor client?

“treatment for all ” is still the TAC request – but what would happen to the health system if all are treated? I guess, it would collapse before we achieve the goal; not sure we should accept promises which cannot be fulfilled – and we know it beforehand. Let’s be honest with giving hope rather than creating disappointment.

We have come a long way since Mbeki’s stance of denial, but we still are living in a somehow tribal organized society where the chiefs are having the say – and our chief preaches protection, but handles his own affairs differently.

Somehow during this interview I once again realise how different the realities are on the different continents, and even on one continent, there is a diversity which must lead to different approaches in the same question. What is good for South Africa might not be good for Uganda or Mali.

And this obviously also applies to the handling of matters in my church – no interview without the special questions about church and prevention and my own struggle within this institution. And also here I try to explain that there are no universal solutions fitting to each and very situation – and that the protection of life in all it’s shade must be priority. No ideal, no ideology, even a Christian one, can replace facing the realities of life. Here and now, with the people in front of me, with all their challenges and weaknesses and possibilities I have to work.

Filed under: HIV and AIDS, HIV Prevention, HIV Treatment, Networking, Politics and Society, Reflection, , , , , , , , ,

Starting packing…

Normally I start packing earliest a day before I leave the country – but this time is different. The World AIDS Awareness Expedition is only starting mid April but already today I started to collect my stuff and to try to pack it nicely. Space is an issue and this morning I tried out to pack parts of the new cloths I organised for the tour to vacuum pack – interesting, funny, but working. It reduces the space quite a bit.. good so.. Last week I went for all the necessary vaccinations – from hepatitis to yellow fever and cholera – I have it all now and lets hope that it works for me and protect my body from becoming sick. I also decided not to take Malaria prophylaxis – it does not make sense to take it for weeks. But I got a test kit to test immediately if I feel I might be bitten by a mosquito and some emergency medication to keep it at bay. The clock is ticking.. in 3 months we are already 4 days on the run…
Move the world – by watching the blog, which will be hopefully updated during my journey every day – so you can follow and be part of this expedition. And maybe the fundraising effort. We are looking for 5 000 000 people donating each 1 Euro – the money is not for supporting the expedition but projects on the 5 continents dealing with HIV/AIDS like HOPE Cape Town. So if you want to be support, information how to do it is coming soon on this blog.

Be part of a great worldwide experience – and help to move the world…

Filed under: HIV and AIDS, HIV Prevention, HIV Treatment, HOPE Cape Town Association & Trust, Networking, Politics and Society, Society and living environment, , , ,

Web-based translation of “God-AIDS-Africa”

The book “God – AIDS – Africa” was published in 2007 telling stories and reflections of the work in the fields of HIV and AIDS and the RC church in South Africa. An English translation is now available for those who want to read the book in their mother tongue. The book is free for reading and further distribution.

http://www.stefanhippler.com/ebook/God-Aids-Africa.html

Filed under: HIV and AIDS, HIV Prevention, HIV Treatment, HOPE Cape Town Association & Trust, Medical and Research, Networking, Politics and Society, Reflection, Society and living environment, , , , , , , , , ,

POZ Magazine: World AIDS Day: 1 Million Now on HIV Meds in South Africa

One million people are now on antiretroviral (ARV) treatment in South Africa, according to an announcement December 1 by South African Deputy President Kgalema Motlanthe, which was reported by Agence France-Presse.
South Africa has one of the highest rates of HIV infection in the world. The United Nations estimates that out of a population of 50 million, 5.6 million are living with HIV. The country went through nearly a decade of inaction on the epidemic—largely a result of then President Thabo Mbeki’s skepticism about the link between HIV and AIDS. This changed toward the end of the past decade, with the implementation of one of the largest ARV distribution programs in the world.
Deputy President Motlanthe and Health Minister Aaron Motsoaledi kicked off their World AIDS Day observation by visiting the homes of households affected by the epidemic in a rural South African village. “What we are observing here is the devastation of HIV/AIDS. All four houses we visited here were headed by grandmothers who are looking after orphans,” said Motsoaledi, adding: “What is left for us is to see how we pick up the pieces.”  Picking up the pieces is something that the country has been quick to do in recent years. The country now has the highest rate of people with HIV on ARV therapy on the African continent, and in the past year it hit this new milestone.
“More than 200,000 new patients have been initiated on ARVs since April this year, bringing a total number to 1 million,” Motlanthe told a public gathering to mark World AIDS Day in the eastern province of Mpumalanga.

Source:  http://www.poz.com/rssredir/articles/hiv_southafrica_antiretroviral_761_19491.shtml

Filed under: HIV and AIDS, HIV Prevention, HIV Treatment, Politics and Society, Society and living environment, , , , ,

POZ Magazine: Protein Discovery Helps Explain the Body’s Failure to Kill HIV

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Researchers at Rush University Medical Center in Chicago have discovered a protein produced by HIV that keeps infected cells from signaling the  immune system that they are harboring the virus and should be killed. These data, which suggest a new target for HIV  drugs, were published online October 18 in the journal Cell Host & Microbe and are discussed in a release available at EurekAlert.
Among the most powerful tools in the immune system’s toolbox for killing infected or defective cells are natural killer (NK) cells. They are unlike HIV-specific CD8 cells, which require a lot of stimulation by other parts of the immune system before they can go into action. NK don’t require virus-specific stimulation before they can recognize and kill infected cells. Yet, for reasons not fully understood, they don’t work the way they should against HIV.

Given the potency of NK cells, and their potential to run amok and kill healthy cells, they must first encounter three different types of proteins on the surface of a potentially infected cell. First, an infected cell needs to express a type of receptor called a major histocompatibiliy (MHC) receptor, which indicates that the cell belongs to the person. The NK cell must also encounter a stimulatory molecule and a costimulatory molecule on the target cell’s surface. If all three of these molecules are present and bind to the corresponding NK cell receptors, then the NK cell will release a chemical that degrades the infected cell.
During the past two decades, immunologists have investigated how NK cells interact with HIV-infected cells, but researchers have long been baffled by a key finding. While the kinds of cellular proteins that are supposed to flag the cell for destruction do get made during the HIV replication process and travel to the surface of the cell, NK cells still fail to recognize and kill them.
It turned out that yet another type of protein called Natural killer T-cell and B-cell Antigen (NTB-A) is also needed at the cell’s surface to alert NK cells that the cell is infected and needs to be destroyed. In the case of HIV, the NTB-A didn’t make it to the surface. Researchers, however, found that HIV did not directly suppress the NTB-A. So why didn’t it make it to the surface to alert the killer cells?
Ankur Shah, PhD, from Rush University, and his colleagues now think they know the answer. Shah’s team found that an accessory protein made by HIV, called Vpu, keeps NTB-A from reaching the cell’s surface. Shah’s team proved this by altering the Vpu protein made by HIV in cells in test tubes and then observing what happened when they added NK cells. The NK cells were 100 times as likely to recognize and kill cells infected with HIV that produced the defective Vpu protein than those infected with HIV that produced the normal Vpu protein.  “With this information, we now have a major new target for drug therapies

Source:   http://www.poz.com/rssredir/articles/hiv_vpu_nkcells_761_19447.shtml

Filed under: HIV and AIDS, HIV Treatment, Medical and Research, , ,

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